Wednesday 3 September 2014 Speaker: Paul Marsden (Kings College, London) Title: "Current Challenges and Opportunities in Positron Emission Tomography" Abstract: Positron Emission Tomography (PET) is now a mainstream clinical imaging technique, its main applications being in the management of patients with cancer. Whole body images of the distribution of pharmaceuticals labelled with positron-emitting radionuclides, notably the glucose analogue fluorodeoxyglucose (FDG) labelled with 18F, are used to determine the stage of disease and monitor how it responds to therapy. PET is also being widely used in the development of new cancer therapies where its use as an ‘imaging biomarker’ to speed up and reduce the cost of clinical trials, and in research studies of brain function, the heart and other parts of the body. The basic principles and applications of PET will be outlined and current challenges and developments will be described with an emphasis on new detector technology.